Stem cell factor and c-kit are involved in hepatic recovery after acetaminophen-induced liver injury in mice.

@article{Hu2008StemCF,
  title={Stem cell factor and c-kit are involved in hepatic recovery after acetaminophen-induced liver injury in mice.},
  author={Bin Hu and Lisa Marie Colletti},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2008},
  volume={295 1},
  pages={G45-G53}
}
Stem cell factor (SCF) and its receptor c-kit are important in hematopoiesis and cellular proliferation. c-kit has also been identified as a cell surface marker for progenitor cells. We have previously shown that there is a large reservoir of hepatic SCF, and this molecule plays a significant role in liver regeneration after 70% hepatectomy. In the current study, we further examined the expression of SCF and c-kit in acetaminophen (APAP)-induced liver injury in C57BL/6J mice or SCF-deficient sl… CONTINUE READING

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