Stem cell factor (SCF), a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 and 12qter

@article{Geissler1991StemCF,
  title={Stem cell factor (SCF), a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 and 12qter},
  author={Edwin N. Geissler and Martha Liao and J. David Brook and Francis H. Martin and Krisztina Maria Zsebo and David E. Housman and Stephen J. Galli},
  journal={Somatic Cell and Molecular Genetics},
  year={1991},
  volume={17},
  pages={207-214}
}
Recently a novel hematopoietic growth factor, stem cell factor (SCF), was cloned and demonstrated to be the ligand for the c-kit tyrosine kinase receptor. In the mouse, SCF is encoded bySl (steel), a gene critical to the development of several distinct cell lineages during embryonic life and which has important effects on hematopoiesis in the adult animal. TheS1/SCF locus maps to the distal region of mouse chromosome 10, in the vicinity of genes that have been mapped to human chromosome 12… 
Expression of the c-kit proto-oncogene and its ligand stem cell factor (SCF) in normal and malignant human testicular tissue.
TLDR
The detection of the c-kit receptor in normal human germ cells and its natural ligand SCF in Sertoli cells suggests the presence of a local trophic regulatory system that may be active in human spermatogenesis.
Emerging functions of c-kit and its ligand stem cell factor in dendritic cells
TLDR
This study shows that induction of c-kit expression and its signaling in DCs promotes Th2 and Th17 responses but not Th1 response, and reviews the differential expression pattern of SCF and c-Kit on various cell types and its avriation during development or pathology.
The Regulation of Mast Cell Development, Survival and Function In Vivo by Stem Cell Factor, the Ligand for the c-kit Receptor: Clinical Implications
TLDR
Findings in phase 1 studies of r-human SCF indicate that r-hSCF can promote the hyperplasia and functional activation of both mast cells and melanocytes, and point to potentially significant new therapeutic opportunities.
Residues 39-56 of Stem Cell Factor Protein Sequence Are Capable of Stimulating the Expansion of Cord Blood CD34+ Cells
TLDR
The peptide P0, corresponding to the SCF protein sequence at residues 39–56, was recognized by 23C8 mAb during ELISA and is a potential candidate for further development as a synthetic substitute for rhSCF in laboratory and clinical applications.
The kit ligand, stem cell factor.
Chromosomal localization of the gene for human B-cell antigen CD40
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Using a panel of human-rodent somatic cell hybrids, it is shown that CD40 maps to human chromosome 20 and had been recently identified and has been assigned to the X chromosome.
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Observations support the view that AML may be considered a dependent neoplasm and that its responsiveness to regulation may be exploited in treatment.
Stem cell factor as a survival and growth factor in human normal and malignant hematopoiesis.
TLDR
The results suggest that the poor response of patients with CD34+ leukemia cells could be at least partially due to less chemotherapy-induced apoptosis resulting from protection by SCF as an adjuvant mechanism for drug resistance in myeloid leukemia.
Peripherin gene is linked to keratin 18 gene on human chromosome 12
TLDR
Linkage analysis showed that the peripherin gene (PRPH) is tightly linked to KRT18, which appears to be in close proximity to a cluster of keratin genes that are clustered in tandem arrays.
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