Stem cell factor (SCF) protects osteoblasts from oxidative stress through activating c-Kit-Akt signaling.

Osteoblasts regulate bone formation and remodeling, and are main target cells of oxidative stress in the progression of osteonecrosis. The stem cell factor (SCF)-c-Kit pathway plays important roles in the proliferation, differentiation and survival in a range of cell types, but little is known about its functions in osteoblasts. In this study, we found that… CONTINUE READING