Stem cell factor/c-Kit interactions regulate human islet-epithelial cluster proliferation and differentiation.

@article{Li2006StemCF,
  title={Stem cell factor/c-Kit interactions regulate human islet-epithelial cluster proliferation and differentiation.},
  author={Jinming Li and Cynthia Gates Goodyer and Fraser Fellows and Rennian Wang},
  journal={The international journal of biochemistry & cell biology},
  year={2006},
  volume={38 5-6},
  pages={961-72}
}
Stem cell factor (SCF), a progenitor cell growth factor, binds to and activates the c-Kit receptor tyrosine kinase, which is critical for early stem cell differentiation in haematopoiesis and gametogenesis. Nothing is known regarding these interactions during islet development in the human fetal pancreas. The present study was to investigate whether an increase in c-Kit receptor activity in isolated human fetal islet-epithelial clusters, by giving exogenous SCF, would promote beta-cell… CONTINUE READING

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