Stem cell factor, but not flt3 ligand, induces differentiation and activation of human mast cells.

@article{Hjertson1996StemCF,
  title={Stem cell factor, but not flt3 ligand, induces differentiation and activation of human mast cells.},
  author={Malin Hjertson and Christer Sundstr{\"o}m and S. D. Lyman and Kenneth Nilsson and Gunnar Nilsson},
  journal={Experimental hematology},
  year={1996},
  volume={24 6},
  pages={748-54}
}
We have examined the effect of human ligand for the flt3/flk2 tyrosine kinase receptor on the differentiation of human mast cells in suspension cultures. We also explored the effect of flt3 ligand (FL) on the human mast cell line HMC-1 and mRNA expression of flt3/flk2 on in vitro developed human mast cells and HMC-1. The growth of cord blood mononuclear cells in suspension cultures was increased when cells were cultured in the presence of FL compared with cells cultured in the presence of stem… CONTINUE READING