Stem cell-derived therapeutic myelin repair requires 7% cell replacement.

@article{Kiel2008StemCT,
  title={Stem cell-derived therapeutic myelin repair requires 7% cell replacement.},
  author={Mary E. Kiel and Cui Ping Chen and Dorota Sadowski and Randall D Mckinnon},
  journal={Stem cells},
  year={2008},
  volume={26 9},
  pages={2229-36}
}
Embryonic stem cells (ESCs) hold great potential for therapeutic regeneration and repair in many diseases. However, many challenges remain before this can be translated into effective therapy. A principal and significant limit for outcome evaluations of clinical trials is to define the minimal graft population necessary for functional repair. Here we used a preclinical model for quantitative analysis of stem cell grafts, with wild-type ESC grafted into myelin mutant shiverer hosts, to determine… CONTINUE READING