Stem cell-derived endochondral cartilage stimulates bone healing by tissue transformation.

@article{Bahney2014StemCE,
  title={Stem cell-derived endochondral cartilage stimulates bone healing by tissue transformation.},
  author={Chelsea S. Bahney and Diane P. Hu and Aaron J Taylor and Federico Ferro and Hayley M Britz and Benedikt Hallgr{\'i}msson and Brian Johnstone and Theodore Miclau and Ralph S Marcucio},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2014},
  volume={29 5},
  pages={1269-82}
}
Although bone has great capacity for repair, there are a number of clinical situations (fracture non-unions, spinal fusions, revision arthroplasty, segmental defects) in which auto- or allografts attempt to augment bone regeneration by promoting osteogenesis. Critical failures associated with current grafting therapies include osteonecrosis and limited integration between graft and host tissue. We speculated that the underlying problem with current bone grafting techniques is that they promote… CONTINUE READING
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