Stem cell competition: finding balance in the niche.

@article{Stine2013StemCC,
  title={Stem cell competition: finding balance in the niche.},
  author={Rachel R W Stine and Erika L. Matunis},
  journal={Trends in cell biology},
  year={2013},
  volume={23 8},
  pages={
          357-64
        }
}
Adult stem cells reside in local microenvironments (niches) that produce signals regulating the outcome of stem cell divisions and stem cell-niche interactions. Limited space and signals in the niche often force stem cells to compete with one another. Although previous studies have uncovered several examples of genetically distinct stem cells competing for niche access, recent studies demonstrate that genetically equivalent stem cells compete under normal conditions, resulting in dynamic stem… CONTINUE READING
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Hematopoietic stem cell heterogeneity takes center stage

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