Stem cell characteristics of dormant cells and cisplatin‑induced effects on the stemness of epithelial ovarian cancer cells.

@article{Zhou2014StemCC,
  title={Stem cell characteristics of dormant cells and cisplatin‑induced effects on the stemness of epithelial ovarian cancer cells.},
  author={Nan Zhou and Xiaohua Wu and Bo Yang and Xu Yang and Dingding Zhang and Guo Qing},
  journal={Molecular medicine reports},
  year={2014},
  volume={10 5},
  pages={
          2495-504
        }
}
Tumor dormancy is a common biological property of malignancies and a leading factor in treatment failure, metastasis and tumor recurrence. The present study generated mouse xenograft models by injection of PKH26‑labeled SKOV3 ovarian cancer cells, which were divided into two groups: The control group (SKOV3‑P tumors,) and the treatment group that generated resistant tumors following prolonged administration of cisplatin (SKOV3‑R tumors). Administration of cisplatin resulted in inhibition of the… CONTINUE READING

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