Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients

@article{Aktas2009StemCA,
  title={Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients},
  author={Bahriye Aktas and Mitra Tewes and Tanja N. Fehm and Siegfried Hauch and Rainer Kimmig and Sabine Kasimir-Bauer},
  journal={Breast Cancer Research : BCR},
  year={2009},
  volume={11},
  pages={R46 - R46}
}
The persistence of circulating tumor cells (CTC) in breast cancer patients might be associated with stem cell like tumor cells which have been suggested to be the active source of metastatic spread in primary tumors. Furthermore, these cells also may undergo phenotypic changes, known as epithelial-mesenchymal transition (EMT), which allows them to travel to the site of metastasis formation without getting affected by conventional treatment. Here we evaluated 226 blood samples of 39 metastatic… CONTINUE READING
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Detection of circulating tumor cells with breast cancer stem cell-like phenotype in blood samples of patients with breast cancer

  • PA Theodoropoulos, H Polioudaki, E Sanidas, S Agelaki, D Mavroudis, V Georgoulias
  • Proc Am Assoc Cancer Res
  • 2008
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