Stem cell aging: mechanisms, regulators and therapeutic opportunities

  title={Stem cell aging: mechanisms, regulators and therapeutic opportunities},
  author={Juhyun Oh and Yang David Lee and Amy J. Wagers},
  journal={Nature Medicine},
Aging tissues experience a progressive decline in homeostatic and regenerative capacities, which has been attributed to degenerative changes in tissue-specific stem cells, stem cell niches and systemic cues that regulate stem cell activity. Understanding the molecular pathways involved in this age-dependent deterioration of stem cell function will be critical for developing new therapies for diseases of aging that target the specific causes of age-related functional decline. Here we explore key… CONTINUE READING
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