Stem and Somatic Cell Monotherapy for the Treatment of Diabetic Foot Ulcers: Review of Clinical Studies and Mechanisms of Action.

@article{Krasilnikova2022StemAS,
  title={Stem and Somatic Cell Monotherapy for the Treatment of Diabetic Foot Ulcers: Review of Clinical Studies and Mechanisms of Action.},
  author={Olga Aleksandrovna Krasilnikova and Denis S. Baranovskii and Aleksey V. Lyundup and P. V. Shegay and Andrey D. Kaprin and Ilya D Klabukov},
  journal={Stem cell reviews and reports},
  year={2022}
}
Diabetic foot ulcer (DFU) is one of the most severe complications of diabetes mellitus, often resulting in a limb amputation. A cell-based therapy is a highly promising approach for an effective DFU treatment. However, there is no consensus regarding the most effective cell type for DFU treatment. Various cell types contribute to chronic wound healing via different mechanisms. For example, application of keratinocytes can stimulate migration of native keratinocytes from the wound edge, while… 
1 Citations
Stem Cells and Angiogenesis: Implications and Limitations in Enhancing Chronic Diabetic Foot Ulcer Healing
TLDR
This article focuses on summarizing and critically reviewing the published literature since 2021 on the use of stem cells to promote angiogenesis and enhance wound healing in chronic non-healing DFUs.

References

SHOWING 1-10 OF 102 REFERENCES
Mesenchymal stromal cell therapy alone does not lead to complete restoration of skin parameters in diabetic foot patients within a 3-year follow-up period
TLDR
MSCs therapy alone did not result in the complete restoration of the skin parameters within a 3-year period, and other novel approaches are required to achieve better results.
Efficacy and Safety of Fresh Fibroblast Allografts in the Treatment of Diabetic Foot Ulcers
TLDR
The use of fresh human fibroblast allografts was found to be a safe and effective treatment for diabetic foot ulcers and patient satisfaction with fresh fibro Blast treatment was superior to satisfaction with the conventional method.
Meta-analysis on the treatment of diabetic foot ulcers with autologous stem cells
TLDR
A systematic review and meta-analysis of the treatment of diabetic foot ulcers with autologous stem cells suggests a promising role for stem cells in DFU treatment and pave the way for further study on the long-term effects of stem cell-based therapy and large-scale RCTs.
Safety and Efficacy of Placenta-Derived Mesenchymal Stem Cell Treatment for Diabetic Patients with Critical Limb Ischemia: A Pilot Study.
  • Jiao Wang, Xiangxia Zeng, Ji-Xiong Xu
  • Medicine
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
  • 2019
TLDR
The data in this pilot study indicated that multiple intramuscular P-MSCs injections may be a safe and effective alternative therapy for diabetic patients with CLI, and larger, placebo-controlled, perspective studies are needed to prove these results.
Randomised controlled clinical trial for autologous fibroblast-hyaluronic acid complex in treating diabetic foot ulcers.
TLDR
Results indicate that autologous fibroblast-hyaluronic acid complex may offer a safe and effective treatment for DFUs, and is likely to result in accelerated diabetic wound healing.
Clinical Evaluation of Human Umbilical Cord Mesenchymal Stem Cell Transplantation After Angioplasty for Diabetic Foot.
  • H. Qin, X. H. Zhu, B. Zhang, L. Zhou, W. Wang
  • Medicine
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
  • 2016
TLDR
The results indicate that HUCMSC transplantation after angioplasty is a safe and effective clinical therapy for severe diabetic foot and no serious complications or adverse reactions were associated with the treatment.
Intralesional allogeneic adipose-derived stem cells application in chronic diabetic foot ulcer: Phase I/2 safety study.
  • Erdal Uzun, A. Güney, M. Mutlu
  • Medicine
    Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons
  • 2020
Allogeneic keratinocyte for intractable chronic diabetic foot ulcers: A prospective observational study
TLDR
Allogeneic keratinocyte treatment is effective for chronic, difficult‐to‐treat DFUs, and patients who showed partial healing continued to receive treatment after the 12‐week study period.
The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers: results of a prospective randomized trial.
TLDR
The results demonstrated that patients with chronic diabetic foot ulcers of >6 weeks duration experienced a significant clinical benefit when treated with Dermagraft versus patients treated with conventional therapy alone.
...
...