Stem-Like Adaptive Aneuploidy and Cancer Quasispecies


We analyze and reinterpret experimental evidence from the literature to argue for an ability of tumor cells to self-regulate their aneuploidy rate. We conjecture that this ability is mediated by a diversification factor that exploits molecular mechanisms common to embryo stem cells and, to a lesser extent, adult stem cells, that is eventually reactivated in… (More)


Cite this paper

@inproceedings{Napoletani2013StemLikeAA, title={Stem-Like Adaptive Aneuploidy and Cancer Quasispecies}, author={Domenico Napoletani and M Signore and Daniele C. Struppa}, year={2013} }