Stem Leydig cell differentiation: gene expression during development of the adult rat population of Leydig cells.

@article{Stanley2011StemLC,
  title={Stem Leydig cell differentiation: gene expression during development of the adult rat population of Leydig cells.},
  author={Erin L Stanley and D. St Johnston and Jinjiang Fan and Vassilios Papadopoulos and Haolin Chen and Ren-Shan Ge and Barry R. Zirkin and Scott A Jelinsky},
  journal={Biology of reproduction},
  year={2011},
  volume={85 6},
  pages={1161-6}
}
Leydig cells are the testosterone-producing cells in the adult male. Adult Leydig cells (ALCs) develop from stem Leydig cells (SLCs) through at least two intermediate cells, progenitor Leydig cells (PLCs) and immature Leydig cells (ILCs). Microarray gene expression was used to identify the transcriptional changes that occur with the differentiation of SLCs to PLCs and, thus, with the entry of SLCs into the Leydig cell lineage; to comprehensively examine differentiation through the development… CONTINUE READING