Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life

@article{Morrison2008StemCA,
  title={Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life},
  author={Sean J Morrison and Allan C. Spradling},
  journal={Cell},
  year={2008},
  volume={132},
  pages={598-611}
}
Niches are local tissue microenvironments that maintain and regulate stem cells. Long-predicted from mammalian studies, these structures have recently been characterized within several invertebrate tissues using methods that reliably identify individual stem cells and their functional requirements. Although similar single-cell resolution has usually not… CONTINUE READING