Stem Cell Therapy for Chronic Pain Management: Review of Uses, Advances, and Adverse Effects.
@article{Chakravarthy2017StemCT, title={Stem Cell Therapy for Chronic Pain Management: Review of Uses, Advances, and Adverse Effects.}, author={Krishnan V. Chakravarthy and Yian Chen and Cathy He and Paul J. Christo}, journal={Pain physician}, year={2017}, volume={20 4}, pages={ 293-305 } }
BACKGROUND
This review article outlines the recent advances, uses, and adverse effects of cell-based therapy for chronic pain management. [] Key MethodSTUDY DESIGN
Narrative review.
METHODS
The Pubmed NCBI and EMBASE databases was utilized to review published reports of clinical studies reported from 2000 to 2015, and ClinicalTrials.gov (www.clinicaltrials.gov/ct2/search) search function was used to document ongoing clinical trials [keywords: "chronic pain," "disc pain," "cell therapy," "osteoarthritis…
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References
SHOWING 1-10 OF 53 REFERENCES
Adult Stem Cell as New Advanced Therapy for Experimental Neuropathic Pain Treatment
- Biology, MedicineBioMed research international
- 2014
The overall positive results obtained on pain remission by using stem cells that are safe, of easy isolation, and which may allow an autologous transplant in patients may be encouraging for moving from bench to bedside, although there are several issues that still need to be solved.
Mesenchymal stem cell therapy for osteoarthritis: current perspectives
- Medicine, BiologyStem cells and cloning : advances and applications
- 2015
Current state of MSC-based therapeutics for OA is summarized and potential barriers that must be overcome are discussed for successful implementation of cell-based therapy as a routine treatment strategy in orthopedics.
A preliminary report on stem cell therapy for neuropathic pain in humans
- MedicineJournal of pain research
- 2014
This preliminary open-labeled study showed autologous administration of stem cells for neuropathic trigeminal pain significantly reduced pain intensity at 6 months and is a safe and well tolerated intervention.
Safety of intra-articular cell-therapy with culture-expanded stem cells in humans: a systematic literature review.
- Medicine, BiologyOsteoarthritis and cartilage
- 2013
Treatment of Knee Osteoarthritis With Autologous Mesenchymal Stem Cells: A Pilot Study
- MedicineTransplantation
- 2013
Assessment of the feasibility and safety of osteoarthritis treatment with mesenchymal stromal cells in humans found the intervention is simple, does not require hospitalization or surgery, provides pain relief, and significantly improves cartilage quality.
Human umbilical cord mesenchymal stem cell transplantation for the treatment of chronic discogenic low back pain.
- MedicinePain physician
- 2014
Clinical outcomes indicated that HUC-MSC transplantation is a favorable alternative method for the treatment of chronic discogenic low back pain.
Treatment of Knee Osteoarthritis With Allogeneic Bone Marrow Mesenchymal Stem Cells: A Randomized Controlled Trial
- Medicine, BiologyTransplantation
- 2015
Allogeneic MSC therapy may be a valid alternative for the treatment of chronic knee osteoarthritis that is more logistically convenient than autologous MSC treatment and significantly improves cartilage quality.
Intervertebral Disc Repair by Autologous Mesenchymal Bone Marrow Cells: A Pilot Study
- Medicine, BiologyTransplantation
- 2011
MSC therapy may be a valid alternative treatment for chronic back pain caused by degenerative disc disease andvantages over current gold standards include simpler and more conservative intervention without surgery, preservation of normal biomechanics, and same or better pain relief.
Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells.
- Medicine, BiologyPain physician
- 2008
The described process of autologous mesenchymal stem cell culture and percutaneous injection into a knee with symptomatic and radiographic degenerative joint disease resulted in significant cartilage growth, decreased pain and increased joint mobility in this patient, which has significant future implications for minimally invasive treatment of osteoarthritis and meniscal injury.
Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients
- Medicine, BiologyInternational journal of rheumatic diseases
- 2011
This data indicates that suppression of pro‐inflammatory cytokines and metalloproteinases in MSC patients with Osteoarthritis is a major cause of disease progression and the use of MSCs for treatment is warranted.