Stem–loop formation drives RNA folding in mechanical unzipping experiments

  title={Stem–loop formation drives RNA folding in mechanical unzipping experiments},
  author={Paolo Rissone and Cristiano Valim Bizarro and Felix Ritort},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
Significance Understanding how complementary RNA single strands anneal to form the native structure requires accurate knowledge of the energetics of hybridization and the kinetics driving the hairpin fold. The annealing dynamics are highly complex for RNA, where multiple long-lived intermediate states occur along the folding pathway. In this framework, single-molecule experiments allow us to derive the thermodynamics and kinetics of RNA folding and the characterization of the intermediates… 

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