Stem/progenitor cells in lung development, injury repair, and regeneration.

  title={Stem/progenitor cells in lung development, injury repair, and regeneration.},
  author={David Warburton and Laura Perin and Roger E Defilippo and Saverio Bellusci and Wei Shi and Barbara A Driscoll},
  journal={Proceedings of the American Thoracic Society},
  volume={5 6},
At least two populations of epithelial stem/progenitor cells give rise to the lung anlage, comprising the laryngo-tracheal complex versus the distal lung below the first bronchial bifurcation. Amplification of the distal population requires FGF9-FGF10-FGFR2b-Sprouty signaling. Residual pools of adult stem cells are hypothesized to be the source of lung regeneration and repair. These pools have been located within the basal layer of the upper airways, within or near pulmonary neuroendocrine cell… CONTINUE READING