Stem/progenitor cell proliferation factors FGF-2, IGF-1, and VEGF exhibit early decline during the course of aging in the hippocampus: role of astrocytes.

@article{Shetty2005StemprogenitorCP,
  title={Stem/progenitor cell proliferation factors FGF-2, IGF-1, and VEGF exhibit early decline during the course of aging in the hippocampus: role of astrocytes.},
  author={Ashok K Shetty and Bharathi Hattiangady and Geetha A. Shetty},
  journal={Glia},
  year={2005},
  volume={51 3},
  pages={173-86}
}
Dentate neurogenesis, important for learning and memory, declines dramatically by middle age. Although studies have shown that this age-related decrease can be reversed to some extent by exogenous applications of mitogenic factors, it is unclear whether one or more of these factors exhibits decline by middle age. We hypothesize that multiple stem/progenitor cell proliferation factors exhibit early decline during the course of aging in the hippocampus, and some of these declines are linked to… CONTINUE READING
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We measured the concentrations of fibroblast growth factor-2 ( FGF-2 ) , insulin - like growth factor-1 ( IGF-1 ) , and vascular endothelial growth factor ( VEGF ) in the hippocampus of young , middle - aged , and aged F344 rats , using enzyme - linked immunosorbent assay ( ELISA ) .
We measured the concentrations of fibroblast growth factor-2 ( FGF-2 ) , insulin - like growth factor-1 ( IGF-1 ) , and vascular endothelial growth factor ( VEGF ) in the hippocampus of young , middle - aged , and aged F344 rats , using enzyme - linked immunosorbent assay ( ELISA ) .
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