Stellate cell contraction: role, regulation, and potential therapeutic target.

Abstract

The contraction of hepatic stellate cells has been proposed to mediate fibrosis by regulating sinusoidal blood flow and extracellular matrix remodeling. Abundant data from diverse, yet complementary, experimental methods support a robust model for the regulation of contractile force generation by stellate cells. In this model, soluble factors associated… (More)
DOI: 10.1016/j.cld.2008.07.004

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