• Corpus ID: 11459726

Stellate Cells Induction Operating in Human Hepatic of Myeloid-Derived Suppressor Cell Peroxide by Catalase Is a Novel Mechanism Contact-Dependent Depletion of Hydrogen

  title={Stellate Cells Induction Operating in Human Hepatic of Myeloid-Derived Suppressor Cell Peroxide by Catalase Is a Novel Mechanism Contact-Dependent Depletion of Hydrogen},
  author={David H. Adams and Dimitrios Mougiakakos and Andreas Mackensen and J. Chris and Blahova and Henning Wolfgang Zimmermann and Regina Jitschin and Abhilok Garg and Stuart M. Curbishley and Miroslava and Yazid J. Resheq and Ka Kit Li and Stephen T Ward},
Myeloid-derived suppressor cells (MDSC) represent a unique cell population with distinct immunosuppressive properties that have been demonstrated to shape the outcome of malignant diseases. Recently, human hepatic stellate cells (HSC) have been reported to induce monocytic-MDSC from mature CD14 + monocytes in a contact-dependent manner. We now report a novel and unexpected mechanism by which CD14 + HLADR low/ 2 suppressive cells are induced by catalase-mediated depletion of hydrogen peroxide (H… 

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