Stella controls chromocenter formation through regulation of Daxx expression in 2-cell embryos.

@article{Arakawa2015StellaCC,
  title={Stella controls chromocenter formation through regulation of Daxx expression in 2-cell embryos.},
  author={Tatsuhiko Arakawa and Tsunetoshi Nakatani and Masaaki Oda and Yasuyoshi Kimura and Yoichi Sekita and Tohru Kimura and Toshinobu Nakamura and Toru Nakano},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={466 1},
  pages={60-5}
}
In mammals, the structure of the pericentromeric region alters from a ring structure to a dot-like structure during the 2-cell stage. This structural alteration is termed chromocenter formation (CF) and is required for preimplantation development. Although reverse transcripts of major satellite repeats at pericentromeric regions are known to play roles in CF, its underlying mechanism is not fully understood. We previously reported that Stella (also known as PGC7 and Dppa3) deficiency led to… CONTINUE READING