Steering cell migration: lamellipodium dynamics and the regulation of directional persistence

  title={Steering cell migration: lamellipodium dynamics and the regulation of directional persistence},
  author={Matthias Krause and Alexis Gautreau},
  journal={Nature Reviews Molecular Cell Biology},
Membrane protrusions at the leading edge of cells, known as lamellipodia, drive cell migration in many normal and pathological situations. Lamellipodial protrusion is powered by actin polymerization, which is mediated by the actin-related protein 2/3 (ARP2/3)-induced nucleation of branched actin networks and the elongation of actin filaments. Recently, advances have been made in our understanding of positive and negative ARP2/3 regulators (such as the SCAR/WAVE (SCAR/WASP family verprolin… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
87 Extracted Citations
214 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 87 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 214 references

guidance mechanisms in solitary and collective cell migration

  • Rorth, P. Whence directionality
  • Dev. Cell 20, 9–18
  • 2011
Highly Influential
9 Excerpts

from simple machinery to complex networks

  • R. H. Insall, Machesky, L. M. Actin dynamics at the leading edge
  • Dev. Cell 17, 310–322
  • 2009
Highly Influential
7 Excerpts

Similar Papers

Loading similar papers…