Steering cell migration: lamellipodium dynamics and the regulation of directional persistence

@article{Krause2014SteeringCM,
  title={Steering cell migration: lamellipodium dynamics and the regulation of directional persistence},
  author={Matthias Krause and Alexis Gautreau},
  journal={Nature Reviews Molecular Cell Biology},
  year={2014},
  volume={15},
  pages={577-590}
}
Membrane protrusions at the leading edge of cells, known as lamellipodia, drive cell migration in many normal and pathological situations. Lamellipodial protrusion is powered by actin polymerization, which is mediated by the actin-related protein 2/3 (ARP2/3)-induced nucleation of branched actin networks and the elongation of actin filaments. Recently, advances have been made in our understanding of positive and negative ARP2/3 regulators (such as the SCAR/WAVE (SCAR/WASP family verprolin… CONTINUE READING
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guidance mechanisms in solitary and collective cell migration

  • Rorth, P. Whence directionality
  • Dev. Cell 20, 9–18
  • 2011
Highly Influential
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from simple machinery to complex networks

  • R. H. Insall, Machesky, L. M. Actin dynamics at the leading edge
  • Dev. Cell 17, 310–322
  • 2009
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