Steel factor is required for maintenance, but not differentiation, of melanocyte precursors in the neural crest.

@article{Murphy1992SteelFI,
  title={Steel factor is required for maintenance, but not differentiation, of melanocyte precursors in the neural crest.},
  author={Maria A. Murphy and Kate Emily Reid and Douglas E. Williams and Stewart D. Lyman and Perry F. Bartlett},
  journal={Developmental biology},
  year={1992},
  volume={153 2},
  pages={396-401}
}
Skin melanocytes are derived from neural crest cells that migrate into the dermis during embryogenesis. Two mouse mutants, Steel and White dominant-spotting, which have defects in melanocyte production, have recently been shown to have deletions in the genes that code for a new growth factor, steel factor (SLF), and its receptor, respectively. Here, we have investigated the role that SLF plays in melanogenesis using cultures of mouse neural crest and found that its primary action is the… CONTINUE READING