• Corpus ID: 18012222

SteatoNet- Modelling steatosis identifies candidate systemic flux distribution deregulations

@article{Naik2013SteatoNetMS,
  title={SteatoNet- Modelling steatosis identifies candidate systemic flux distribution deregulations},
  author={Adviti Naik and Damjana Rozman and Ales Belic},
  journal={arXiv: Molecular Networks},
  year={2013}
}
The functional diversity in factors identified in association with non-alcoholic fatty liver disease (NAFLD) necessitates the utilization of holistic approaches to investigate the network properties of NAFLD pathogenesis. We describe the generation of the first mouse-specific multi-tissue metabolic model, the SteatoNet, to investigate NAFLD-related steatosis, by utilising an object-oriented modelling approach and incorporating numerous hepatic metabolic pathways, their interaction with… 
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References

SHOWING 1-10 OF 112 REFERENCES
Molecular Interactions between NAFLD and Xenobiotic Metabolism
TLDR
A better understanding of the complex interplay betweenNAFLD pathogenesis and drug metabolism is a prerequisite for developing improved drug dosing algorithms for the pharmacotherapy of patients with different stages of NAFLD.
Systems Biology Elucidates Common Pathogenic Mechanisms between Nonalcoholic and Alcoholic-Fatty Liver Disease
TLDR
Systems biology revealed the importance of each molecular process behind each of the two diseases, and dissected distinctive molecular NAFLD and AFLD-signatures.
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
TLDR
Altered interactions between the gut microbiota and the host, produced by defective NLRP3 and NLRP6 inflammasome sensing, may govern the rate of progression of multiple metabolic syndrome-associated abnormalities, highlighting the central role of the microbiota in the pathogenesis of heretofore seemingly unrelated systemic auto-inflammatory and metabolic disorders.
Adipose Tissue Dysfunction Signals Progression of Hepatic Steatosis Towards Nonalcoholic Steatohepatitis in C57Bl/6 Mice
TLDR
The data support the existence of a tight relationship between adipose tissue dysfunction and NASH pathogenesis and point to several novel potential predictive biomarkers for NASH.
HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology
TLDR
HepatoNet1 is presented, the first reconstruction of a comprehensive metabolic network of the human hepatocyte that is shown to accomplish a large canon of known metabolic liver functions and how the availability of nutrients and oxygen may modulate the interplay of various metabolic pathways to allow an efficient response of the liver to perturbations of the homeostasis of blood compounds.
Hepatic Gene Networks in Morbidly Obese Patients With Nonalcoholic Fatty Liver Disease
TLDR
This study reveals the canonical pathways and gene networks associated with NAFLD in morbidly obese Caucasians and highlights the transcriptional relationships amongNAFLD-associated genes and allows identification of hub genes that may represent high-priority candidates for NAFLd.
Genomic aspects of NAFLD pathogenesis.
Nonalcoholic Fatty Liver Disease: Focus on Lipoprotein and Lipid Deregulation
TLDR
This paper focuses on pathogenic aspect of lipid and lipoprotein metabolism in NAFLD and the relevant mouse models of this complex multifactorial disease.
Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH.
Obesity Affects the Liver – The Link between Adipocytes and Hepatocytes
TLDR
This review summarizes current knowledge – highlighting the inflammatory and cytokine view – of the intimate relationship between adipose and liver tissue and suggests reduced adiponectin levels may establish a proinflammatory milieu, thus increasing vulnerability to lipotoxicity.
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