• Corpus ID: 18012222

SteatoNet- Modelling steatosis identifies candidate systemic flux distribution deregulations

  title={SteatoNet- Modelling steatosis identifies candidate systemic flux distribution deregulations},
  author={Adviti Naik and Damjana Rozman and Ales Belic},
  journal={arXiv: Molecular Networks},
The functional diversity in factors identified in association with non-alcoholic fatty liver disease (NAFLD) necessitates the utilization of holistic approaches to investigate the network properties of NAFLD pathogenesis. We describe the generation of the first mouse-specific multi-tissue metabolic model, the SteatoNet, to investigate NAFLD-related steatosis, by utilising an object-oriented modelling approach and incorporating numerous hepatic metabolic pathways, their interaction with… 

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