Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure.

@article{Sun2003StearoylCoADI,
  title={Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure.},
  author={Yu Sun and Mingming Hao and Yi Luo and Chien-ping Liang and David L Silver and Celina Cheng and Frederick R Maxfield and Alan Richard Tall},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 8},
  pages={5813-20}
}
Liver X receptor/retinoid X receptor (LXR/RXR) transcription factors have been found to induce a number of genes involved in the regulation of cellular cholesterol efflux, including the ATP-binding cassette transporter A1 (ABCA1), which mediates the active efflux of cellular cholesterol and phospholipids to extracellular acceptors, such as apolipoprotein A-I (apoA-I). In a screen for macrophage LXR/RXR target genes, we identified stearoyl-CoA desaturases 1 and 2 (Scd1 and Scd2), and… CONTINUE READING
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