Stearoyl-CoA desaturase-1 is associated with insulin resistance in morbidly obese subjects.

@article{GarcaSerrano2011StearoylCoADI,
  title={Stearoyl-CoA desaturase-1 is associated with insulin resistance in morbidly obese subjects.},
  author={Sara Garc{\'i}a-Serrano and Inmaculada Moreno-Santos and Lourdes Garrido-S{\'a}nchez and Carolina Guti{\'e}rrez-Repiso and Jos{\'e} Manuel Garc{\'i}a-Almeida and Juan Antonio Garc{\'i}a-Arn{\'e}s and Jose Rivas-Mar{\'i}n and Jose Luis Gallego-Perales and Eva Garc{\'i}a-Escobar and Gemma Rojo-Mart{\'i}nez and Francisco J Tinahones and Federico C Soriguer and Manuel Mac{\'i}as-Gonz{\'a}lez and Eduardo Garc{\'i}a-Fuentes},
  journal={Molecular medicine},
  year={2011},
  volume={17 3-4},
  pages={
          273-80
        }
}
Animal studies have revealed the association between stearoyl-CoA desaturase 1 (SCD1) and obesity and insulin resistance. However, only a few studies have been undertaken in humans. We studied SCD1 in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) from morbidly obese patients and their association with insulin resistance, sterol regulatory element binding protein-1 (SREBP-1) and ATPase p97, proteins involved in SCD1 synthesis and degradation. The insulin resistance was… CONTINUE READING

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