Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms.

@article{Miyazaki2004StearoylCoAD1,
  title={Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms.},
  author={Makoto Miyazaki and Agnieszka Dobrzyń and Weng Chi Man and Kiki Chu and Harini Sampath and Hyoun-ju Kim and James M. Ntambi},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 24},
  pages={25164-71}
}
Stearoyl-CoA desaturase (SCD) synthesizes oleate necessary for the biosynthesis of triglycerides and other lipids. Mice with a targeted disruption of the SCD1 gene are deficient in tissue oleate and have reduced expression of the sterol regulatory element-binding protein (SREBP) and its target genes. The SREBP-1c isoform is a known mediator of insulin action on hepatic gene expression, but its transcriptional effects due to glucose or fructose are still unclear. We found that fructose compared… CONTINUE READING
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