Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice.

@article{Miyazaki2009StearoylCoADD,
  title={Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice.},
  author={Makoto Miyazaki and Harini Sampath and Xueqing Liu and Matthew T. Flowers and Kiki Chu and Agnieszka Dobrzyń and James M. Ntambi},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={380 4},
  pages={818-22}
}
Obesity and adiposity greatly increase the risk for secondary conditions such as insulin resistance. Mice deficient in the enzyme stearoyl-CoA desaturase-1 (SCD1) are lean and protected from diet-induced obesity and insulin resistance. In order to determine the effect of SCD1 deficiency on various mouse models of obesity, we introduced a global deletion of the Scd1 gene into leptin-deficient ob/ob mice, leptin-resistant Agouti (A(y)/a) mice, and high-fat diet-fed obese (DIO) mice. SCD1… CONTINUE READING