Stearoyl-CoA desaturase: rogue or innocent bystander?

  title={Stearoyl-CoA desaturase: rogue or innocent bystander?},
  author={Leanne Hodson and Barbara A. Fielding},
  journal={Progress in lipid research},
  volume={52 1},
Different lipid fractions in humans have characteristic fatty acid profiles and these are maintained partly through diet and to a lesser extent through endogenous synthesis. The enzyme stearoyl-CoA desaturase (SCD; EC is the rate-limiting enzyme in the synthesis of monounsaturated fatty acids such as palmitoleic acid (16:1 n-7) and oleic acid (18:1 n-9). These are the two most abundant monounsaturated fatty acids in human plasma lipids, membranes and adipose tissue. Although in… CONTINUE READING


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