Steamed and Fermented Ethanolic Extract from Codonopsis lanceolata Attenuates Amyloid-β-Induced Memory Impairment in Mice

  title={Steamed and Fermented Ethanolic Extract from Codonopsis lanceolata Attenuates Amyloid-$\beta$-Induced Memory Impairment in Mice},
  author={Jin Bae Weon and Min Rye Eom and Youn Sik Jung and Eun-Hye Hong and Hyun-Jeong Ko and Hyeon Yong Lee and Dongsik Park and Choong Je Ma},
  journal={Evidence-based Complementary and Alternative Medicine : eCAM},
  • J. Weon, Min Rye Eom, +5 authors C. Ma
  • Published 2016
  • Chemistry, Medicine
  • Evidence-based Complementary and Alternative Medicine : eCAM
Codonopsis lanceolata (C. lanceolata) is a traditional medicinal plant used for the treatment of certain inflammatory diseases such as asthma, tonsillitis, and pharyngitis. We evaluated whether steamed and fermented C. lanceolata (SFC) extract improves amyloid-β- (Aβ-) induced learning and memory impairment in mice. The Morris water maze and passive avoidance tests were used to evaluate the effect of SFC extract. Moreover, we investigated acetylcholinesterase (AChE) activity and brain-derived… Expand
Ficus erecta Thunb. Leaves Ameliorate Cognitive Deficit and Neuronal Damage in a Mouse Model of Amyloid-β-Induced Alzheimer’s Disease
EEFE protects against cognitive deficit and neuronal damage in AD-like mice via activation of the CREB/BDNF signaling and upregulation of the inflammatory cytokines. Expand
Codonopsis lanceolata Water Extract Increases Hepatic Insulin Sensitivity in Rats with Experimentally-Induced Type 2 Diabetes
In conclusion, CLW consumption effectively alleviated diabetic symptoms by improving insulin sensitivity, potentiating hepatic insulin signaling and tightly regulating the insulin secretion capacity in non-obese T2DM rats. Expand
Biotransformation of 5-hydroxymethylfurfural into 2,5-dihydroxymethylfuran by Ganoderma sessile and toxicological assessment of both compounds
Results suggest it is feasible to convert 5-HMF to DHMF via crude enzymes from fungus G. sessile under mild condition, and that DHMF displays a potential effect of antitumor in vitro with little acute toxicity. Expand
Biotransformation of 5-hydroxymethylfurfural into 2,5-dihydroxymethylfuran by Ganoderma sessile and toxicological assessment of both compounds.
Biotransformation has the advantages of low cost and environmental protection and is a preferred method for production of compounds. At present, most 2,5-dihydroxymethylfuran (DHMF) is synthesized byExpand
Lancemaside A from Codonopsis lanceolata prevents hypertension by inhibiting NADPH oxidase 2‐mediated MAPK signalling and improving NO bioavailability in rats
This study investigated whether lancemaside A (LMA) can prevent hypertension and assessed the mechanisms of action of LMA in rats and found that LMA can be used to treat hypertension in rats. Expand


Cognitive-Enhancing Effect of Steamed and Fermented Codonopsis lanceolata: A Behavioral and Biochemical Study
  • J. Weon, Bo-Ra Yun, +7 authors C. Ma
  • Medicine
  • Evidence-based complementary and alternative medicine : eCAM
  • 2014
Results indicate that fermented C. lanceolata can ameliorate scopolamine-induced memory deficits in mouse and may be an alternative agent for the treatment of AD. Expand
Inhibitory effect of saponin fraction from Codonopsis lanceolata on immune cell-mediated inflammatory responses
Results suggest that saponin fraction (SF) may be considered as a promising herbal medicine with potent anti-inflammatory actions. Expand
Lancemaside A isolated from Codonopsis lanceolata and its metabolite echinocystic acid ameliorate scopolamine-induced memory and learning deficits in mice.
Lancemaside A and echinocystic acid significantly reversed scopolamine-induced memory and learning deficits on the Y-maze and Morris water maze tasks and increased the expression of brain-derived neurotrophic factor (BDNF) and phosphorylated cAMP response element binding protein (p-CREB). Expand
Fustin flavonoid attenuates β‐amyloid (1–42)‐induced learning impairment
Fustin attenuates Aβ (1–42)‐impaired learning, and the ERK/CREB/BDNF pathway is important for the M1 receptor‐mediated cognition‐enhancing effects of fustin. Expand
Triterpenoid saponins and anti-inflammatory activity of Codonopsis lanceolata.
The ethanolic root extract of Codonopsis lanceolata were evaluated for anti-inflammatory activity using the carrageenan induced rat hind paw edema model and displayed a significant activity of 51.82%Expand
Effect of Codonopsis lanceolatae Extracts on Mouse IL-2, IFN-${\gamma}$, IL-10 Cytokine Production by Peritoneal Macrophage and the Ratio of IFN-${\gamma}$, IL-10 Cytokine
It is suggested that Codonopsis lanceolatae extracts may enhance the immune function by regulating the cytokine(IL-2, IL-10 and IFN-) prodution capacity by activated macrophages in mice. Expand
Preparative separation of the saponin lancemaside a from Codonopsis lanceolata by centrifugal partition chromatography.
A simple and efficient method for the preparative isolation of lancemaside A along with two other saponins, foetidissimoside A and astersaponin Hb, from the saponin fraction of C. lanceolata was established using CPC. Expand
Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide
The data obtained show that the enhancement of AChE activity induced by Abeta(25-35) is mediated by oxidative stress, and that vitamin E and NOS inhibitors can have an important role in the maintenance of acetylcholine synaptic levels, thus preventing or improving cognitive and memory functions of AD patients. Expand
Triterpene glycosides from the roots of Codonopsis lanceolata.
The constituents of the polar fraction of the roots of C. lanceolata were studied and six new triterpene saponins, lancemasides B, C, D, L, and G were identified, thought to be oleanan-type bisdesmoside with sugars at C-3 and C-28 and echinocystic acid as an aglycone. Expand
Reduced neuroplasticity in aged rats: a role for the neurotrophin brain-derived neurotrophic factor
The results demonstrate that the BDNF system is affected at different levels in aged rats with global impairment including reduced transcription, impaired protein synthesis and processing, and decreased activation of the TrkB receptors, and suggest that pharmacological strategies aimed at restoring reduced neurotrophism might be useful to counteract age-related cognitive decline. Expand