Steamed and Fermented Ethanolic Extract from Codonopsis lanceolata Attenuates Amyloid-β-Induced Memory Impairment in Mice

@article{Weon2016SteamedAF,
  title={Steamed and Fermented Ethanolic Extract from Codonopsis lanceolata Attenuates Amyloid-$\beta$-Induced Memory Impairment in Mice},
  author={Jin Bae Weon and Min Rye Eom and Youn Sik Jung and Eun-Hye Hong and Hyun-Jeong Ko and Hyeon Yong Lee and Dongsik Park and Choong Je Ma},
  journal={Evidence-based Complementary and Alternative Medicine : eCAM},
  year={2016},
  volume={2016}
}
  • J. Weon, Min Rye Eom, +5 authors C. Ma
  • Published 2016
  • Chemistry, Medicine
  • Evidence-based Complementary and Alternative Medicine : eCAM
Codonopsis lanceolata (C. lanceolata) is a traditional medicinal plant used for the treatment of certain inflammatory diseases such as asthma, tonsillitis, and pharyngitis. We evaluated whether steamed and fermented C. lanceolata (SFC) extract improves amyloid-β- (Aβ-) induced learning and memory impairment in mice. The Morris water maze and passive avoidance tests were used to evaluate the effect of SFC extract. Moreover, we investigated acetylcholinesterase (AChE) activity and brain-derived… Expand
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  • J. Weon, Bo-Ra Yun, +7 authors C. Ma
  • Medicine
  • Evidence-based complementary and alternative medicine : eCAM
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TLDR
Lancemaside A and echinocystic acid significantly reversed scopolamine-induced memory and learning deficits on the Y-maze and Morris water maze tasks and increased the expression of brain-derived neurotrophic factor (BDNF) and phosphorylated cAMP response element binding protein (p-CREB). Expand
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TLDR
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TLDR
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