Steady-state serum pharmacokinetics of novobiocin and rifampin alone and in combination.

Abstract

Because of the potential of novobiocin-rifampin for oral therapy of methicillin-resistant Staphylococcus aureus infection, we evaluated the pharmacokinetics of novobiocin and rifampin, alone and in combination, in a randomized, crossover, multiple-dose evaluation (500 mg of novobiocin and 300 mg of rifampin administered orally, twice a day, for 27 doses) in… (More)

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@article{Drusano1986SteadystateSP, title={Steady-state serum pharmacokinetics of novobiocin and rifampin alone and in combination.}, author={George L. Drusano and R. J. Townsend and Thomas Walsh and Alistair R R Forrest and E-A. Antal and Harold C. Standiford}, journal={Antimicrobial agents and chemotherapy}, year={1986}, volume={30 1}, pages={42-5} }