Steady state pharmacokinetics of idebenone in patients with moderate hepatic impairment.

@article{Coto1992SteadySP,
  title={Steady state pharmacokinetics of idebenone in patients with moderate hepatic impairment.},
  author={Vincenzo Coto and Ugo Oliviero and Paolo P Sorrentino and Manlio Cocozza and Paolo De Paola and M Lingetti},
  journal={Archives of gerontology and geriatrics},
  year={1992},
  volume={15 3},
  pages={207-14}
}
The kinetics of idebenone (45 mg twice daily p.o.) in 6 Caucasian chronic hepatopathic patients without portal hypertension were studied. The pharmacokinetic parameters were evaluated both for single (day 1) and multiple (day 10) administrations. These 6 patients showed a first order bi-compartimental kinetic curve for idebenone and for its metabolites… CONTINUE READING