Steady-state pharmacokinetics of delavirdine in HIV-positive patients: effect on erythromycin breath test.


OBJECTIVE The steady-state kinetics of delavirdine and desisopropyldelavirdine were evaluated in human immunodeficiency virus-positive patients after escalating oral doses and after repeated oral administrations at the same dose level. STUDY DESIGN Patients (n = 8 males) were given escalating oral doses of delavirdine mesylate, in a sequential fashion… (More)


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