Steady-state pharmacokinetics and tissue distribution of anthraquinones of Rhei Rhizoma in rats.

@article{Shia2011SteadystatePA,
  title={Steady-state pharmacokinetics and tissue distribution of anthraquinones of Rhei Rhizoma in rats.},
  author={Chi-Sheng Shia and Shang-Yuan Tsai and Jung-Chih Lin and Ming-li Li and M L Ko and Pei-dawn Lee Chao and Yu-Ching Huang and Y Y Hou},
  journal={Journal of ethnopharmacology},
  year={2011},
  volume={137 3},
  pages={1388-94}
}
AIM OF THE STUDY Rhei Rhizoma, the rhizome of Rheum palmatum L. (RP), is a popular herb in clinical Chinese medicine. RP is abundant in polyphenolic anthraquinones, which have been reported to show various beneficial bioactivities. This study investigated the pharmacokinetics and tissue distribution of anthraquinones following seven-dose administration of RP decoction to rats. MATERIALS AND METHODS Six Sprague-Dawley rats were given 2.0 g/kg of RP twice daily for seven doses and blood samples… CONTINUE READING
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