Steady-state kinetics of the schistosomal hypoxanthine-guanine phosphoribosyltransferase.

  title={Steady-state kinetics of the schistosomal hypoxanthine-guanine phosphoribosyltransferase.},
  author={Liming Yuan and Steven P. Craig and James H McKerrow and Ching C. Wang},
  volume={31 3},
Schistosomiasis is a trematode infection of some 200 million people. The hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) of the major etiologic agent, Schistosoma mansoni, has been proposed as a potential target for antischistosomal chemotherapy [Dovey, H. F., McKerrow, J. H., & Wang, C. C. (1984) Mol. Biochem. Parasitol, 11, 157-167]. The steady-state kinetic mechanism for the schistosomal HGPRTase has been determined by including both hypoxanthine and guanine in the forward and… CONTINUE READING