Steady-state kinetics of imipramine in patients


Steady-state plasma level kinetics were studied in 76 patients given imipramine (IP) 150 to 225 mg/day for 2–5 weeks. IP was given in three divided doses at 8.00 a.m., 1.00 p.m. and 5.00 p.m. Plasma concentrations of IP and its active metabolite desipramine (DMI) were determined by quantitative in situ thin-layer chromatography. The plasma levels of IP and… (More)
DOI: 10.1007/BF00426573


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@article{Gram1977SteadystateKO, title={Steady-state kinetics of imipramine in patients}, author={Lars Freng Gram and Ib S\ondergaard and Johannes Christiansen and Gorm Odden Petersen and Per Bech and Niels Reisby and Ilse Ibsen and J. Ortmann and Adam Zsolt Nagy and Sven Jonas Dencker and Ove Jacobsen and Ole Krautwald}, journal={Psychopharmacology}, year={1977}, volume={54}, pages={255-261} }