Steady-state fluctuations of a genetic feedback loop: an exact solution.

@article{Grima2012SteadystateFO,
  title={Steady-state fluctuations of a genetic feedback loop: an exact solution.},
  author={Ramon Grima and Daniel Schmidt and Timothy Newman},
  journal={The Journal of chemical physics},
  year={2012},
  volume={137 3},
  pages={035104}
}
Genetic feedback loops in cells break detailed balance and involve bimolecular reactions; hence, exact solutions revealing the nature of the stochastic fluctuations in these loops are lacking. We here consider the master equation for a gene regulatory feedback loop: a gene produces protein which then binds to the promoter of the same gene and regulates its expression. The protein degrades in its free and bound forms. This network breaks detailed balance and involves a single bimolecular… CONTINUE READING

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