Steady or changing? Long-term monitoring of neuronal population activity

  title={Steady or changing? Long-term monitoring of neuronal population activity},
  author={Henry L{\"u}tcke and David J. Margolis and Fritjof Helmchen},
  journal={Trends in Neurosciences},
Stability and flexibility are both hallmarks of brain function that allow animals to thrive in ever-changing environments. Investigating how a balance between these opposing features is achieved with a dynamic array of cellular and molecular constituents requires long-term tracking of activity from individual neurons. Here, we review in vivo chronic extracellular recording studies and recent long-term two-photon calcium-imaging investigations that address the question of stability and… CONTINUE READING

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