Ste50 adaptor protein governs sexual differentiation of Cryptococcus neoformans via the pheromone-response MAPK signaling pathway.

@article{Jung2011Ste50AP,
  title={Ste50 adaptor protein governs sexual differentiation of Cryptococcus neoformans via the pheromone-response MAPK signaling pathway.},
  author={Kwang-Woo Jung and Seo-Young Kim and Laura Hana Okagaki and Kirsten Helms Nielsen and Yong-Sun Bahn},
  journal={Fungal genetics and biology : FG & B},
  year={2011},
  volume={48 2},
  pages={
          154-65
        }
}
The mitogen-activated protein kinase (MAPK) pathways control diverse cellular functions in pathogenic fungi, including sexual differentiation, stress response, and maintenance of cell wall integrity. Here we characterized a Cryptococcus neoformans gene, which is homologous to the yeast Ste50 that is known to play an important role in mating pheromone response and stress response as an adaptor protein to the Ste11 MAPK kinase kinase in Saccharomyces cerevisiae. The C. neoformans Ste50 was not… CONTINUE READING
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