Ste20-related kinase SLK phosphorylates Ser188 of RhoA to induce vasodilation in response to angiotensin II Type 2 receptor activation.

@article{Guilluy2008Ste20relatedKS,
  title={Ste20-related kinase SLK phosphorylates Ser188 of RhoA to induce vasodilation in response to angiotensin II Type 2 receptor activation.},
  author={Christophe Guilluy and Malvyne Rolli-Derkinderen and Laurent Loufrani and Anne Bourg{\'e} and Daniel Henrion and Luc A. Sabourin and Gervaise Loirand and Pierre Pacaud},
  journal={Circulation research},
  year={2008},
  volume={102 10},
  pages={
          1265-74
        }
}
The small G protein Rho signaling pathways are recognized as major regulators of cardiovascular functions, and activation of Rho proteins appears to be a common component for the pathogenesis of hypertension and vascular proliferative disorders. Recent evidence suggests that modulation of Rho protein signaling by phosphorylation of Rho proteins provides an additional simple mechanism for coordinating Rho protein functions. Phosphorylation of RhoA by cAMP- or cGMP-activated kinase on Ser188… CONTINUE READING
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