Stavudine-loaded mannosylated liposomes: in-vitro anti-HIV-I activity, tissue distribution and pharmacokinetics.

@article{Garg2006StavudineloadedML,
  title={Stavudine-loaded mannosylated liposomes: in-vitro anti-HIV-I activity, tissue distribution and pharmacokinetics.},
  author={Minakshi Garg and Abhay Asthana and Hrushikesh Bharat Agashe and Govind Prasad Agrawal and Narendra Kumar Jain},
  journal={The Journal of pharmacy and pharmacology},
  year={2006},
  volume={58 5},
  pages={605-16}
}
Cells of the mononuclear phagocyte system (MPS) are important hosts for human immunodeficiency virus (HIV). Lectin receptors, which act as molecular targets for sugar molecules, are found on the surface of these cells of the MPS. Stavudine-loaded mannosylated liposomal formulations were developed for targeting to HIV-infected cells. The mannose-binding protein concanavalin A was employed as model system for the determination of in-vitro ligand-binding capacity. Antiretroviral activity was… CONTINUE READING

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