Staurosporine is chemoprotective by inducing G1 arrest in a Chk1- and pRb-dependent manner.


Chemotherapeutic agents have been the mainstay of cancer therapy for years. However, their effectiveness has been limited by toxicities they impart on normal cells. Staurosporine (ST) has been shown to arrest normal, but not breast cancer, cells in G1. Therefore, ST may become a chemoprotective agent, arresting normal cells while allowing tumor cells to… (More)
DOI: 10.1093/carcin/bgt186



Citations per Year

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