Staurosporine induces a complete program of terminal differentiation in neoplastic mouse keratinocytes via activation of protein kinase C.

@article{Stanwell1996StaurosporineIA,
  title={Staurosporine induces a complete program of terminal differentiation in neoplastic mouse keratinocytes via activation of protein kinase C.},
  author={C Stanwell and Andrzej A Dlugosz and Stuart H. Yuspa},
  journal={Carcinogenesis},
  year={1996},
  volume={17 6},
  pages={1259-65}
}
Staurosporine (stsp) is a kinase inhibitor which induces cornified envelope assembly and terminal differentiation in normal and neoplastic mouse keratinocytes. In the tumorigenic cell lines 308 and SP-1 experiments were performed to determine if this effect was due only to activation of transglutaminases (TGases) already residing within the cell, or whether stsp was capable of inducing a full program of differentiation. Assessment of keratinocyte differentiation-specific protein expression in… CONTINUE READING

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