Staurosporine-induced apoptosis in cardiomyocytes: A potential role of caspase-3.

  title={Staurosporine-induced apoptosis in cardiomyocytes: A potential role of caspase-3.},
  author={Tian-li Yue and Chaojian Wang and Anne M. Romanic and Kristine Kikly and Pernille Keller and Walter E. deWolf and Timothy K. Hart and Heath C Thomas and Barry Storer and Jiali Gu and Xin Wang and Giora G Z Feuerstein},
  journal={Journal of molecular and cellular cardiology},
  volume={30 3},
Cardiomyocyte apoptosis has been demonstrated in animal models of cardiac injury as well as in patients with congestive heart failure or acute myocardial infarction. Therefore, apoptosis has been proposed as an important process in cardiac remodeling and progression of myocardial dysfunction. However, the mechanisms underlying cardiac apoptosis are poorly understood. The present study was designed to determine whether the family of caspase proteases and stress-activated protein kinase (SAPK/JNK… CONTINUE READING


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