Staufen2 regulates neuronal target RNAs.

  title={Staufen2 regulates neuronal target RNAs.},
  author={Jacki E. Heraud-Farlow and Tejaswini Sharangdhar and Xiao Ou Li and Philipp Pfeifer and Stefanie Tauber and Denise Orozco and Alexandra H{\"o}rmann and Sabine Thomas and Anetta Bakosova and Ashley R Farlow and Dieter Edbauer and Howard D. Lipshitz and Quaid Morris and Martin H Bilban and Michael P Doyle and Michael A Kiebler},
  journal={Cell reports},
  volume={5 6},
RNA-binding proteins play crucial roles in directing RNA translation to neuronal synapses. Staufen2 (Stau2) has been implicated in both dendritic RNA localization and synaptic plasticity in mammalian neurons. Here, we report the identification of functionally relevant Stau2 target mRNAs in neurons. The majority of Stau2-copurifying mRNAs expressed in the hippocampus are present in neuronal processes, further implicating Stau2 in dendritic mRNA regulation. Stau2 targets are enriched for… CONTINUE READING
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