Status of colony-stimulating factors in cancer and AIDS.

  title={Status of colony-stimulating factors in cancer and AIDS.},
  author={Jerome E. Groopman},
  journal={Seminars in oncology},
  volume={17 1 Suppl 1},
  pages={31-7; discussion 38-41}
The major hematopoietic growth factors have been produced through recombinant DNA technology and have entered initial clinical trials; results of these trials will be reviewed here. Granulocyte colony-stimulating factor (G-CSF) has been tested in patients with bladder cancer and small-cell carcinoma of the lung. In these studies, G-CSF ameliorated the leukopenia associated with combination chemotherapy, reduced the incidence of mucositis in the bladder cancer patients, and nearly eliminated the… CONTINUE READING