Status epilepticus during old age is not associated with enhanced hippocampal neurogenesis.

@article{Rao2008StatusED,
  title={Status epilepticus during old age is not associated with enhanced hippocampal neurogenesis.},
  author={Muddanna S. Rao and Bharathi Hattiangady and Ashok K. Shetty},
  journal={Hippocampus},
  year={2008},
  volume={18 9},
  pages={
          931-44
        }
}
Increased production of new neurons in the adult dentate gyrus (DG) by neural stem/progenitor cells (NSCs) following acute seizures or status epilepticus (SE) is a well known phenomenon. However, it is unknown whether NSCs in the aged DG have similar ability to upregulate neurogenesis in response to SE. We examined DG neurogenesis after the induction of continuous stages III-V seizures (SE) for over 4 h in both young adult (5-months old) and aged (24-months old) F344 rats. The seizures were… CONTINUE READING

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