Stattic V, a STAT3 inhibitor, affects human spermatozoa through regulation of mitochondrial activity.

@article{Lachance2013StatticVA,
  title={Stattic V, a STAT3 inhibitor, affects human spermatozoa through regulation of mitochondrial activity.},
  author={Catherine Lachance and Serge Goupil and Pierre Leclerc},
  journal={Journal of cellular physiology},
  year={2013},
  volume={228 4},
  pages={704-13}
}
We have recently shown that many mediators of the JAK/STAT signaling pathway are present in ejaculated human spermatozoa. Among them, STAT3 is detected mainly in membranes and flagellar cytoskeletal fractions. In order to determine the importance of STAT3-mediated signaling, sperm were incubated with Stattic V, a specific inhibitor. Effects on motility were evaluated by CASA, sperm acrosomal integrity was evaluated by FITC conjugated lectin (PSA or PNA) staining, and protein phosphotyrosine… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Mitochondrial Stat3, the Need for Design Thinking.

International journal of biological sciences • 2016
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…