# Statistical tests of models of DNA substitution

@article{Goldman2004StatisticalTO, title={Statistical tests of models of DNA substitution}, author={Nick Goldman}, journal={Journal of Molecular Evolution}, year={2004}, volume={36}, pages={182-198} }

SummaryPenny et al. have written that “The most fundamental criterion for a scientific method is that the data must, in principle, be able to reject the model. Hardly any [phylogenetic] tree-reconstruction methods meet this simple requirement.” The ability to reject models is of such great importance because the results of all phylogenetic analyses depend on their underlying models—to have confidence in the inferences, it is necessary to have confidence in the models. In this paper, a test…

## 543 Citations

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Although this chapter focuses on models of nucleotide substitution, all the points made herein can be applied directly to models of amino-acid replacement, and maximum likelihood provides a framework in this chapter.

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The results partly explain the lack of consensus over estimates of the long-term evolutionary time scale of these viruses, and indicate that assessing the adequacy of substitution models should be routinely used to determine whether estimates are reliable.

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